There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to reduce afferent pain transmission and create analgesia. Consequently, medication like clonidine that goal alpha-2 receptors can impact the transmission of discomfort. Applies to clonidine: oral tablet, oral pill https://push2bookmark.com/story19971597/onolidine-fundamentals-explained