From the LSD-bound crystal composition, the side chain of your lid residue L209EL2 types extensive hydrophobic contacts with both of those LSD and encompassing residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to show the binding pocket in simulation, numerous of these contacts broke. https://archerahbrr.blogofchange.com/35716287/limited-edition-exclusive-lsd-crystal-no-further-a-mystery