So that you can rationalise the noticed ABL kinase inhibitory effects from a 3D structural perspective, the direct compounds I and II, and also the newly designed derivatives 4a, 4b, and five have been docked while in the catalytic kinase domains of BCR-ABLWT (PDB code: 3OXZ) and BCR-ABLT315I (PDB code: https://indazoleproducts20864.total-blog.com/indazole-1-things-to-know-before-you-buy-56399873