Opioid activity is because of equally low affinity binding with the mother or father compound and higher affinity binding from the O-demethylated metabolite M1 to μ-opioid receptors. In animal designs, M1 is nearly six periods far more strong than tramadol in creating analgesia and 200 moments extra potent in μ-opioid https://timj676anx7.newsbloger.com/profile